Two sample MR report
HLA-DQB1_Conventional Dendritic Cell against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 15 | 0.0460197 | 0.1390522 | 0.7459539 |
| Weighted median | 15 | -0.0438237 | 0.0173567 | 0.0115737 |
| Inverse variance weighted | 15 | -0.0340911 | 0.0139919 | 0.0148308 |
| Simple mode | 15 | -0.0449124 | 0.0282491 | 0.1341848 |
| Weighted mode | 15 | -0.0446742 | 0.0288433 | 0.1437199 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 2.418592 | 13 | 0.9993487 |
| Inverse variance weighted | 2.753902 | 14 | 0.9994349 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0547734 | 0.0945902 | 0.5724466 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0004389 | 0 | TRUE | 0.0461864 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
